Yes.
More context is better than less, and it would likely be more useful to others reading this to understand what specific action you are talking about, so in future, I recommend widening out those screen shots to provide that context. For the benefit of those other readers, in this case, it's a Run Reaction action. There is a similar checkbox for HTTP Request.
Also as a general comment, you asked specifically about Set and Reset reactions, but all of this conversation applies to all reactions, including global.
